Cloned (Comment) | Organism |
---|---|
gene IP6K1 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of enzyme-deficient Ip6k1-/- mice, phenotype, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
x * 55000, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol hexakisphosphate | Mus musculus | - |
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol hexakisphosphate | Mus musculus C57BL/6 | - |
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q6PD10 | - |
- |
Mus musculus | Q6PD10 | gene IP6K1 | - |
Mus musculus C57BL/6 | Q6PD10 | gene IP6K1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Mus musculus | - |
MEF cell | - |
Mus musculus | - |
megakaryocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol hexakisphosphate | - |
Mus musculus | ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol hexakisphosphate | - |
Mus musculus C57BL/6 | ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
inositol hexakisphosphate kinase 1 | - |
Mus musculus |
IP6 kinase 1 | - |
Mus musculus |
IP6K1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | significant reduction in platelet polyP levels in enzyme-deficient Ip6k1-/- mice, along with slower platelet aggregation and lengthened plasma clotting time. Incorporation of polyP into fibrin clots is reduced in Ip6k1-/- mice, thereby altering clot ultrastructure, which is rescued on the addition of exogenous polyP. In vivo assays reveal longer tail bleeding time and resistance to thromboembolism in Ip6k1-/- mice. No alteration in P-selectin surface expression in Ip6k1-/- platelets implies that IP6K1 does not influence platelet alpha-granule content or its thrombin-stimulated release No difference in the extent of fibrinogen binding to activated wild-type or Ip6k1-/- platelets, and no difference in serotonin content. Knockout Ip6k1-/- mice show altered clot homogeneity and architecture and a significant increase in the number of fibers per unit length in Ip6k1-/- derived clots compared to wild-type. Hemostasis defects in Ip6k1-/- mice, overview | Mus musculus |
physiological function | inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels. Role for IP6K1 in regulation of mammalian hemostasis via its control of platelet polyP levels | Mus musculus |